1a6f: Difference between revisions

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[[Image:1a6f.gif|left|200px]]


<!--
==RNASE P PROTEIN FROM BACILLUS SUBTILIS==
The line below this paragraph, containing "STRUCTURE_1a6f", creates the "Structure Box" on the page.
<StructureSection load='1a6f' size='340' side='right'caption='[[1a6f]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1a6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A6F FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1a6f| PDB=1a6f |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6f OCA], [https://pdbe.org/1a6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a6f RCSB], [https://www.ebi.ac.uk/pdbsum/1a6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a6f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RNPA_BACSU RNPA_BACSU] RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/1a6f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a6f ConSurf].
<div style="clear:both"></div>


'''RNASE P PROTEIN FROM BACILLUS SUBTILIS'''
==See Also==
 
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The crystal structure of Bacillus subtilis ribonuclease P protein is reported at 2.6 angstroms resolution. This protein binds to ribonuclease P RNA to form a ribonucleoprotein holoenzyme with optimal catalytic activity. Mutagenesis and biochemical data indicate that an unusual left-handed betaalphabeta crossover connection and a large central cleft in the protein form conserved RNA binding sites; a metal binding loop may comprise a third RNA binding site. The unusual topology is partly shared with ribosomal protein S5 and the ribosomal translocase elongation factor G, which suggests evolution from a common RNA binding ancestor in the primordial translational apparatus.
 
==About this Structure==
1A6F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6F OCA].
 
==Reference==
Ribonuclease P protein structure: evolutionary origins in the translational apparatus., Stams T, Niranjanakumari S, Fierke CA, Christianson DW, Science. 1998 May 1;280(5364):752-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9563955 9563955]
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Ribonuclease P]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Christianson DW]]
[[Category: Christianson, D W.]]
[[Category: Stams T]]
[[Category: Stams, T.]]
[[Category: Endonuclease]]
[[Category: Rnase]]
[[Category: Subunit]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:53:00 2008''

Latest revision as of 06:28, 7 February 2024

RNASE P PROTEIN FROM BACILLUS SUBTILIS

1a6f, resolution 2.60Å

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