1af3: Difference between revisions

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{{Seed}}
[[Image:1af3.png|left|200px]]


<!--
==RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN==
The line below this paragraph, containing "STRUCTURE_1af3", creates the "Structure Box" on the page.
<StructureSection load='1af3' size='340' side='right'caption='[[1af3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1af3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AF3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1af3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1af3 OCA], [https://pdbe.org/1af3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1af3 RCSB], [https://www.ebi.ac.uk/pdbsum/1af3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1af3 ProSAT]</span></td></tr>
{{STRUCTURE_1af3| PDB=1af3 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/B2CL1_RAT B2CL1_RAT] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:8662675</ref> <ref>PMID:7828536</ref> <ref>PMID:18250306</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/1af3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1af3 ConSurf].
<div style="clear:both"></div>


===RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN===
==See Also==
 
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_9346936}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 9346936 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_9346936}}
 
==About this Structure==
1AF3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AF3 OCA].
 
==Reference==
<ref group="xtra">PMID:9346936</ref><references group="xtra"/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Aritomi, M.]]
[[Category: Aritomi M]]
[[Category: Inohara, N.]]
[[Category: Inohara N]]
[[Category: Ishibashi, Y.]]
[[Category: Ishibashi Y]]
[[Category: Kunishima, N.]]
[[Category: Kunishima N]]
[[Category: Morikawa, K.]]
[[Category: Morikawa K]]
[[Category: Ohta, S.]]
[[Category: Ohta S]]
[[Category: Alternative splicing]]
[[Category: Apoptosis]]
[[Category: Bcl-xl]]
[[Category: Mitochondrion]]
[[Category: Regulatory protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:44:22 2009''
Retrieved from "https://proteopedia.org/1af3"