1br3: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1br3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BR3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1br3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BR3 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1br3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1br3 OCA], [https://pdbe.org/1br3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1br3 RCSB], [https://www.ebi.ac.uk/pdbsum/1br3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1br3 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1br3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1br3 OCA], [https://pdbe.org/1br3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1br3 RCSB], [https://www.ebi.ac.uk/pdbsum/1br3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1br3 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of a large nucleic acid complex formed by the 10-23 DNA enzyme bound to an RNA substrate was determined by X-ray diffraction at 3.0 A resolution. The 82-nucleotide complex contains two strands of DNA and two strands of RNA that form five double-helical domains. The spatial arrangement of these helices is maintained by two four-way junctions that exhibit extensive base-stacking interactions and sharp turns of the phosphodiester backbone stabilized by metal ions coordinated to nucleotides at these junctions. Although it is unlikely that the structure corresponds to the catalytically active conformation of the enzyme, it represents a novel nucleic acid fold with implications for the Holliday junction structure.
Crystal structure of an 82-nucleotide RNA-DNA complex formed by the 10-23 DNA enzyme.,Nowakowski J, Shim PJ, Prasad GS, Stout CD, Joyce GF Nat Struct Biol. 1999 Feb;6(2):151-6. PMID:10048927<ref>PMID:10048927</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1br3" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Joyce, G F]]
[[Category: Joyce GF]]
[[Category: Nowakowski, J]]
[[Category: Nowakowski J]]
[[Category: Prasad, G S]]
[[Category: Prasad GS]]
[[Category: Shim, P J]]
[[Category: Shim PJ]]
[[Category: Stout, C D]]
[[Category: Stout CD]]
[[Category: Dna enzyme]]
[[Category: Dna-rna hybrid]]
[[Category: Dna-rna hybrid complex]]
[[Category: Dna/rna hybrid]]
[[Category: Holliday junction]]
[[Category: Ribozyme]]

Latest revision as of 06:38, 7 February 2024

CRYSTAL STRUCTURE OF AN 82-NUCLEOTIDE RNA-DNA COMPLEX FORMED BY THE 10-23 DNA ENZYME

1br3, resolution 3.00Å

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