1csl: Difference between revisions

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[[Image:1csl.jpg|left|200px]]


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==CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE==
The line below this paragraph, containing "STRUCTURE_1csl", creates the "Structure Box" on the page.
<StructureSection load='1csl' size='340' side='right'caption='[[1csl]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1csl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CSL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csl OCA], [https://pdbe.org/1csl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1csl RCSB], [https://www.ebi.ac.uk/pdbsum/1csl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1csl ProSAT]</span></td></tr>
{{STRUCTURE_1csl|  PDB=1csl  |  SCENE= }}
</table>
 
__TOC__
'''CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE'''
</StructureSection>
 
[[Category: Large Structures]]
 
[[Category: Ippolito JA]]
==Overview==
[[Category: Steitz TA]]
The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-purine base-pairs and two single nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies.
 
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA].  
 
==Reference==
The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution., Ippolito JA, Steitz TA, J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10656783 10656783]
[[Category: Ippolito, J A.]]
[[Category: Steitz, T A.]]
[[Category: Hiv-1]]
[[Category: Rre high affinity site]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:04:18 2008''
Retrieved from "https://proteopedia.org/1csl"