1d1l: Difference between revisions

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{{Seed}}
[[Image:1d1l.png|left|200px]]


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==CRYSTAL STRUCTURE OF CRO-F58W MUTANT==
The line below this paragraph, containing "STRUCTURE_1d1l", creates the "Structure Box" on the page.
<StructureSection load='1d1l' size='340' side='right'caption='[[1d1l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1d1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D1L FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1d1l|  PDB=1d1l  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1l OCA], [https://pdbe.org/1d1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d1l RCSB], [https://www.ebi.ac.uk/pdbsum/1d1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d1l ProSAT]</span></td></tr>
 
</table>
===CRYSTAL STRUCTURE OF CRO-F58W MUTANT===
== Function ==
 
[https://www.uniprot.org/uniprot/RCRO_LAMBD RCRO_LAMBD] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_10686105}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 10686105 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/1d1l_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_10686105}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1D1L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1L OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d1l ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
The structural basis for enhanced stability and reduced DNA binding seen in engineered second-generation Cro monomers and dimers., Rupert PB, Mollah AK, Mossing MC, Matthews BW, J Mol Biol. 2000 Mar 3;296(4):1079-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10686105 10686105]
</StructureSection>
[[Category: Enterobacteria phage lambda]]
[[Category: Escherichia virus Lambda]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Matthews, B W.]]
[[Category: Matthews BW]]
[[Category: Mollah, A K.]]
[[Category: Mollah AK]]
[[Category: Mossing, M C.]]
[[Category: Mossing MC]]
[[Category: Rupert, P B.]]
[[Category: Rupert PB]]
[[Category: Helix-turn-helix]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:05:48 2008''
Retrieved from "https://proteopedia.org/1d1l"