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| | ==CRYSTAL STRUCTURE AT 1.5 ANGSTROMS RESOLUTION OF D(CGCICICG), AN OCTANUCLEOTIDE CONTAINING INOSINE, AND ITS COMPARISON WITH D(CGCG) AND D(CGCGCG) STRUCTURES== |
| The line below this paragraph, containing "STRUCTURE_1d53", creates the "Structure Box" on the page.
| | <StructureSection load='1d53' size='340' side='right'caption='[[1d53]], [[Resolution|resolution]] 1.50Å' scene=''> |
| You may change the PDB parameter (which sets the PDB file loaded into the applet)
| | == Structural highlights == |
| or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| | <table><tr><td colspan='2'>[[1d53]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D53 FirstGlance]. <br> |
| or leave the SCENE parameter empty for the default display.
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
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| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d53 OCA], [https://pdbe.org/1d53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d53 RCSB], [https://www.ebi.ac.uk/pdbsum/1d53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d53 ProSAT]</span></td></tr> |
| {{STRUCTURE_1d53| PDB=1d53 | SCENE= }}
| | </table> |
| | | __TOC__ |
| '''CRYSTAL STRUCTURE AT 1.5 ANGSTROMS RESOLUTION OF D(CGCICICG), AN OCTANUCLEOTIDE CONTAINING INOSINE, AND ITS COMPARISON WITH D(CGCG) AND D(CGCGCG) STRUCTURES'''
| | </StructureSection> |
| | | [[Category: Large Structures]] |
| | | [[Category: Andrews LC]] |
| ==Overview== | | [[Category: Harrison RW]] |
| The octadeoxyribonucleotide d(CGCICICG) has been crystallized in space group P(6)5(22) with unit cell dimensions of a = b = 31.0 A and c = 43.7 A, and X-ray diffraction data have been collected to 1.5-A resolution. Precession photographs and the self-Patterson function indicate that 12 base pairs of Z-conformation DNA stack along the c-axis, and the double helices pack in a hexagonal array similar to that seen in other crystals of Z-DNA. The structure has been solved by both Patterson deconvolution and molecular replacement methods and refined in space group P(6)5 to an R factor of 0.225 using 2503 unique reflections greater than 3.0 sigma (F). Comparison of the molecules within the hexagonal lattice with highly refined crystal structures of other Z-DNA reveals only minor conformational differences, most notably in the pucker of the deoxyribose of the purine residues. The DNA has multiple occupancy of C:I and C:G base pairs, and C:I base pairs adopt a conformation similar to that of C:G base pairs.
| | [[Category: Kumar VD]] |
| | | [[Category: Weber IT]] |
| ==About this Structure== | |
| Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D53 OCA]. | |
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| ==Reference== | |
| Crystal structure at 1.5-A resolution of d(CGCICICG), an octanucleotide containing inosine, and its comparison with d(CGCG) and d(CGCGCG) structures., Kumar VD, Harrison RW, Andrews LC, Weber IT, Biochemistry. 1992 Feb 11;31(5):1541-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1737011 1737011]
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| [[Category: Andrews, L C.]]
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| [[Category: Harrison, R W.]] | |
| [[Category: Kumar, V D.]] | |
| [[Category: Weber, I T.]] | |
| [[Category: Double helix]] | |
| [[Category: Z-dna]] | |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:52:19 2008''
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