1d90: Difference between revisions

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[[Image:1d90.gif|left|200px]]


{{Structure
==REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS==
|PDB= 1d90 |SIZE=350|CAPTION= <scene name='initialview01'>1d90</scene>, resolution 1.700&Aring;
<StructureSection load='1d90' size='340' side='right'caption='[[1d90]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DI:2&#39;-DEOXYINOSINE-5&#39;-MONOPHOSPHATE'>DI</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
<table><tr><td colspan='2'>[[1d90]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D90 FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
|GENE=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d90 OCA], [https://pdbe.org/1d90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d90 RCSB], [https://www.ebi.ac.uk/pdbsum/1d90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d90 ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
__TOC__
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d90 OCA], [http://www.ebi.ac.uk/pdbsum/1d90 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d90 RCSB]</span>
</StructureSection>
}}
[[Category: Large Structures]]
 
[[Category: Aymani J]]
'''REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS'''
[[Category: Brown T]]
 
[[Category: Cruse WBT]]
 
[[Category: Jack AGC]]
==Overview==
[[Category: Kennard O]]
The structure of the synthetic deoxyoctamer d(GGIGCTCC) has been determined by single crystal X-ray diffraction techniques to a resolution of 1.7A. The sequence crystallises in space group P6(1), with unit cell dimensions a = b = 45.07, c = 45.49A. The refinement converged with a crystallographic residual R = 0.14 and the location of 81 solvent molecules. The octamer forms an A-DNA duplex with 6 Watson-Crick (G.C) base pairs and 2 inosine-thymine (I.T) pairs. Refinement of the structure shows it to be essentially isomorphous with that reported for d(GGGGCTCC) with the mispairs adopting a "wobble" conformation. Conformational parameters and base stacking interactions are compared to those for the native duplex d(GGGGCCCC) and other similar sequences. A rationale for the apparent increased crystal packing efficiency and lattice stability of the I.T octamer is given.
[[Category: Leonard GA]]
 
==About this Structure==
1D90 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D90 OCA].
 
==Reference==
Refined crystal structure of an octanucleotide duplex with I.T. mismatched base pairs., Cruse WB, Aymani J, Kennard O, Brown T, Jack AG, Leonard GA, Nucleic Acids Res. 1989 Jan 11;17(1):55-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2911488 2911488]
[[Category: Protein complex]]
[[Category: Aymani, J.]]
[[Category: Brown, T.]]
[[Category: Cruse, W B.T.]]
[[Category: Jack, A G.C.]]
[[Category: Kennard, O.]]
[[Category: Leonard, G A.]]
[[Category: a-dna]]
[[Category: double helix]]
[[Category: mismatched]]
[[Category: modified]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:36:57 2008''
Retrieved from "https://proteopedia.org/1d90"