1dll: Difference between revisions
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< | ==The HC fragement of tetanus toxin complexed with lactose== | ||
<StructureSection load='1dll' size='340' side='right'caption='[[1dll]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1dll]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dll OCA], [https://pdbe.org/1dll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dll RCSB], [https://www.ebi.ac.uk/pdbsum/1dll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dll ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/1dll_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dll ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Tetanus toxin|Tetanus toxin]] | |||
__TOC__ | |||
</StructureSection> | |||
< | |||
[[Category: Clostridium tetani]] | [[Category: Clostridium tetani]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Black | [[Category: Black I]] | ||
[[Category: Charles | [[Category: Charles IG]] | ||
[[Category: Emsley | [[Category: Emsley P]] | ||
[[Category: Fairweather | [[Category: Fairweather NF]] | ||
[[Category: Fotinou | [[Category: Fotinou C]] | ||
[[Category: Hewitt | [[Category: Hewitt E]] | ||
[[Category: Isaacs | [[Category: Isaacs NW]] | ||
[[Category: Watts | [[Category: Watts C]] | ||
Latest revision as of 06:55, 7 February 2024
The HC fragement of tetanus toxin complexed with lactose
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