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New page: left|200px<br /><applet load="1dr5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dr5, resolution 2.4Å" /> '''CRYSTAL STRUCTURES OF...
 
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[[Image:1dr5.gif|left|200px]]<br /><applet load="1dr5" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1dr5, resolution 2.4&Aring;" />
'''CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES'''<br />


==About this Structure==
==CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES==
1DR5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with HG, CA and NAP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DR5 OCA].  
<StructureSection load='1dr5' size='340' side='right'caption='[[1dr5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
[[Category: Dihydrofolate reductase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[1dr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DR5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dr5 OCA], [https://pdbe.org/1dr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dr5 RCSB], [https://www.ebi.ac.uk/pdbsum/1dr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dr5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_CHICK DYR_CHICK] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/1dr5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dr5 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: /II, J.F.Davies.]]
[[Category: Davies /II JF]]
[[Category: Kaufman, B.T.]]
[[Category: Kaufman BT]]
[[Category: Kraut, J.]]
[[Category: Kraut J]]
[[Category: Mctigue, M.A.]]
[[Category: Mctigue MA]]
[[Category: Xuong, N.H.]]
[[Category: Xuong N-H]]
[[Category: CA]]
[[Category: HG]]
[[Category: NAP]]
[[Category: oxidoreductase]]
 
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