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[[Image:1f08.png|left|200px]]


{{STRUCTURE_1f08| PDB=1f08 | SCENE= }}
==CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN E1 FROM PAPILLOMAVIRUS==
<StructureSection load='1f08' size='340' side='right'caption='[[1f08]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1f08]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_papillomavirus Bovine papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F08 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f08 OCA], [https://pdbe.org/1f08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f08 RCSB], [https://www.ebi.ac.uk/pdbsum/1f08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f08 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VE1_BPV1 VE1_BPV1] ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/1f08_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f08 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN E1 FROM PAPILLOMAVIRUS===
==See Also==
 
*[[Replication protein E1|Replication protein E1]]
 
__TOC__
==About this Structure==
</StructureSection>
[[1f08]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus Bovine papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F08 OCA].
 
==Reference==
<ref group="xtra">PMID:010949036</ref><ref group="xtra">PMID:017253903</ref><references group="xtra"/>
[[Category: Bovine papillomavirus]]
[[Category: Bovine papillomavirus]]
[[Category: Chen, G.]]
[[Category: Large Structures]]
[[Category: Enemark, E J.]]
[[Category: Chen G]]
[[Category: Joshua-Tor, L.]]
[[Category: Enemark EJ]]
[[Category: Stenlund, A.]]
[[Category: Joshua-Tor L]]
[[Category: Vaughn, D E.]]
[[Category: Stenlund A]]
[[Category: Dna-binding domain]]
[[Category: Vaughn DE]]
[[Category: Helicase]]
[[Category: Initiator protein]]
[[Category: Papillomavirus]]
[[Category: Replication]]
Retrieved from "https://proteopedia.org/1f08"