1fr9: Difference between revisions

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{{Seed}}
[[Image:1fr9.png|left|200px]]


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==STRUCTURE OF E. COLI MOBA==
The line below this paragraph, containing "STRUCTURE_1fr9", creates the "Structure Box" on the page.
<StructureSection load='1fr9' size='340' side='right'caption='[[1fr9]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1fr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FR9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1fr9|  PDB=1fr9  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fr9 OCA], [https://pdbe.org/1fr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1fr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fr9 ProSAT]</span></td></tr>
 
</table>
===STRUCTURE OF E. COLI MOBA===
== Function ==
 
[https://www.uniprot.org/uniprot/MOBA_ECOLI MOBA_ECOLI] Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Is also involved in the biosynthesis of the bis-MGD form of the Moco cofactor (Mo-bisMGD) in which the metal is symmetrically ligated by the dithiolene groups of two MGD molecules. Is necessary and sufficient for the in vitro activation of the DMSOR molybdoenzyme that uses the Mo-bisMGD form of molybdenum cofactor, which implies formation and efficient insertion of the cofactor into the enzyme without the need of a chaperone. Is specific for GTP since other nucleotides such as ATP and GMP can not be utilized.<ref>PMID:8020507</ref> <ref>PMID:1648082</ref> <ref>PMID:10978348</ref> <ref>PMID:21081498</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/1fr9_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_10978347}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1FR9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FR9 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fr9 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis., Lake MW, Temple CA, Rajagopalan KV, Schindelin H, J Biol Chem. 2000 Dec 22;275(51):40211-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10978347 10978347]
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Lake, M W.]]
[[Category: Lake MW]]
[[Category: Rajagopalan, K V.]]
[[Category: Rajagopalan KV]]
[[Category: Schindelin, H.]]
[[Category: Schindelin H]]
[[Category: Temple, C A.]]
[[Category: Temple CA]]
[[Category: Moco biosynthesis]]
 
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Retrieved from "https://proteopedia.org/1fr9"