1ft8: Difference between revisions

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{{Seed}}
[[Image:1ft8.png|left|200px]]


<!--
==CRYSTAL STRUCTURE OF THE RNA-BINDING DOMAIN OF THE MRNA EXPORT FACTOR TAP==
The line below this paragraph, containing "STRUCTURE_1ft8", creates the "Structure Box" on the page.
<StructureSection load='1ft8' size='340' side='right'caption='[[1ft8]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ft8]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FT8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ft8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ft8 OCA], [https://pdbe.org/1ft8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ft8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ft8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ft8 ProSAT]</span></td></tr>
{{STRUCTURE_1ft8|  PDB=1ft8  |  SCENE=  }}
</table>
 
== Function ==
===CRYSTAL STRUCTURE OF THE RNA-BINDING DOMAIN OF THE MRNA EXPORT FACTOR TAP===
[https://www.uniprot.org/uniprot/NXF1_HUMAN NXF1_HUMAN] Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.<ref>PMID:9660949</ref> <ref>PMID:19165146</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_11060011}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 11060011 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/1ft8_consurf.spt"</scriptWhenChecked>
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    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_11060011}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ft8 ConSurf].
1FT8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FT8 OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain., Liker E, Fernandez E, Izaurralde E, Conti E, EMBO J. 2000 Nov 1;19(21):5587-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11060011 11060011]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Conti, E.]]
[[Category: Conti E]]
[[Category: Fernandez, E.]]
[[Category: Fernandez E]]
[[Category: Izaurralde, E.]]
[[Category: Izaurralde E]]
[[Category: Liker, E.]]
[[Category: Liker E]]
[[Category: Rrm]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:54:51 2008''

Latest revision as of 07:19, 7 February 2024

CRYSTAL STRUCTURE OF THE RNA-BINDING DOMAIN OF THE MRNA EXPORT FACTOR TAP

1ft8, resolution 3.15Å

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