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[[Image:1isc.png|left|200px]]


{{STRUCTURE_1isc|  PDB=1isc  |  SCENE=  }}
==STRUCTURE-FUNCTION IN E. COLI IRON SUPEROXIDE DISMUTASE: COMPARISONS WITH THE MANGANESE ENZYME FROM T. THERMOPHILUS==
 
<StructureSection load='1isc' size='340' side='right'caption='[[1isc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===STRUCTURE-FUNCTION IN E. COLI IRON SUPEROXIDE DISMUTASE: COMPARISONS WITH THE MANGANESE ENZYME FROM T. THERMOPHILUS===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1isc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ISC FirstGlance]. <br>
{{ABSTRACT_PUBMED_7849024}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1isc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1isc OCA], [https://pdbe.org/1isc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1isc RCSB], [https://www.ebi.ac.uk/pdbsum/1isc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1isc ProSAT]</span></td></tr>
[[1isc]] is a 2 chain structure of [[Superoxide Dismutase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISC OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/SODF_ECOLI SODF_ECOLI] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/1isc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1isc ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Superoxide Dismutase|Superoxide Dismutase]]
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:007849024</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Superoxide dismutase]]
[[Category: Large Structures]]
[[Category: Dixon, M.]]
[[Category: Dixon M]]
[[Category: Fee, J A.]]
[[Category: Fee JA]]
[[Category: Lah, M S.]]
[[Category: Lah MS]]
[[Category: Ludwig, M L.]]
[[Category: Ludwig ML]]
[[Category: Pattridge, K A.]]
[[Category: Pattridge KA]]
[[Category: Stallings, W C.]]
[[Category: Stallings WC]]
Retrieved from "https://proteopedia.org/1isc"