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[[Image:1jd5.png|left|200px]]


{{STRUCTURE_1jd5|  PDB=1jd5  |  SCENE=  }}
==Crystal Structure of DIAP1-BIR2/GRIM==
 
<StructureSection load='1jd5' size='340' side='right'caption='[[1jd5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===Crystal Structure of DIAP1-BIR2/GRIM===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1jd5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JD5 FirstGlance]. <br>
{{ABSTRACT_PUBMED_11511363}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jd5 OCA], [https://pdbe.org/1jd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jd5 RCSB], [https://www.ebi.ac.uk/pdbsum/1jd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jd5 ProSAT]</span></td></tr>
[[1jd5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JD5 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/DIAP1_DROME DIAP1_DROME] Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8-E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid-dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppress Dronc-mediated cell death through Diap1-mediated ubiquitination of Dronc. Acts as a positive regulator of Wnt signaling.<ref>PMID:14517550</ref> <ref>PMID:17397804</ref> <ref>PMID:18259196</ref> <ref>PMID:21145488</ref> <ref>PMID:22304967</ref> <ref>PMID:8548811</ref>
<ref group="xtra">PMID:011511363</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jd/1jd5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jd5 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Chai, J.]]
[[Category: Large Structures]]
[[Category: Cocina, A E.]]
[[Category: Chai J]]
[[Category: Hay, B A.]]
[[Category: Cocina AE]]
[[Category: Shi, Y.]]
[[Category: Hay BA]]
[[Category: Wu, J W.]]
[[Category: Shi Y]]
[[Category: Apoptosis]]
[[Category: Wu JW]]
[[Category: Caspase activation]]
[[Category: Drosophila]]
[[Category: Grim]]
[[Category: Hydrolase-peptide complex]]
[[Category: Iap]]
Retrieved from "https://proteopedia.org/1jd5"