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New page: left|200px<br /><applet load="1jes" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jes, resolution 1.5Å" /> '''Crystal Structure of ...
 
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[[Image:1jes.gif|left|200px]]<br /><applet load="1jes" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1jes, resolution 1.5&Aring;" />
'''Crystal Structure of a Copper-Mediated Base Pair in DNA'''<br />


==Overview==
==Crystal Structure of a Copper-Mediated Base Pair in DNA==
Stable and selective DNA base pairing by metal coordination was recently, demonstrated with nucleotides containing complementary, pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.;, Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am., Chem. Soc. 2000, 122, 10714-10715). To understand the structural, consequences of introducing this novel base pair into DNA we have solved, the crystal structure of a duplex containing the metallo-base pair. The, structure shows that the bases pair as designed, but in a Z-DNA, conformation. The structure also provides a structural explanation for the, B- to Z-DNA transition in this duplex. Further solution studies, demonstrate that the metallo-base pair is compatible with Z- or B-DNA, conformations, depending on the duplex sequence.
<StructureSection load='1jes' size='340' side='right'caption='[[1jes]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1jes]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JES FirstGlance]. <br>
1JES is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with CU as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=DPY:2-DEOXYRIBOFURANOSYL-PYRIDINE-2,6-DICARBOXYLIC+ACID-5-MONOPHOSPHATE'>DPY</scene>, <scene name='pdbligand=DRP:2-DEOXYRIBOFURANOSYL-PYRIDINE-5-MONOPHOSPHATE'>DRP</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jes OCA], [https://pdbe.org/1jes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jes RCSB], [https://www.ebi.ac.uk/pdbsum/1jes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jes ProSAT]</span></td></tr>
Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11734038 11734038]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Atwell, S.]]
</StructureSection>
[[Category: Meggers, E.]]
[[Category: Large Structures]]
[[Category: Schultz, P.G.]]
[[Category: Atwell S]]
[[Category: Spraggon, G.]]
[[Category: Meggers E]]
[[Category: CU]]
[[Category: Schultz PG]]
[[Category: copper]]
[[Category: Spraggon G]]
[[Category: cu]]
[[Category: designed]]
[[Category: dna]]
[[Category: dodecamer]]
[[Category: duplex]]
[[Category: metal]]
[[Category: unnatural]]
[[Category: z-dna]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:32:36 2007''

Latest revision as of 07:39, 7 February 2024

Crystal Structure of a Copper-Mediated Base Pair in DNA

1jes, resolution 1.50Å

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