5jp4: Difference between revisions
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==Crystal structure of S. pombe Dcp1 in complex with the decapping enhancer EDC== | |||
<StructureSection load='5jp4' size='340' side='right'caption='[[5jp4]], [[Resolution|resolution]] 2.04Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jp4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JP4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.043Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jp4 OCA], [https://pdbe.org/5jp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jp4 RCSB], [https://www.ebi.ac.uk/pdbsum/5jp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jp4 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DCP1_SCHPO DCP1_SCHPO] Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:15671491</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Schizosaccharomyces pombe]] | |||
[[Category: Sprangers R]] | |||
[[Category: Wurm JP]] | |||
Latest revision as of 07:47, 7 February 2024
Crystal structure of S. pombe Dcp1 in complex with the decapping enhancer EDC
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