5lab: Difference between revisions

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'''Unreleased structure'''


The entry 5lab is ON HOLD
==Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor NNGH==
<StructureSection load='5lab' size='340' side='right'caption='[[5lab]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5lab]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LAB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lab OCA], [https://pdbe.org/5lab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lab RCSB], [https://www.ebi.ac.uk/pdbsum/5lab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lab ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.


Authors: Ravera, E., Calderone, V., Luchinat, C.
==See Also==
 
*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
Description: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor NNGH
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Calderone, V]]
[[Category: Homo sapiens]]
[[Category: Ravera, E]]
[[Category: Large Structures]]
[[Category: Luchinat, C]]
[[Category: Calderone V]]
[[Category: Luchinat C]]
[[Category: Ravera E]]
Retrieved from "https://proteopedia.org/5lab"