5nbx: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry 5nbx is ON HOLD~~

==ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-9]-OH==

~~Authors: Barone, M., Roske, Y.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5nbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NBX OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5NBX FirstGlance].

~~Description:~~ ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-9]-OH

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2L5:2-CHLORO-L-PHENYLALANINE'>2L5</scene>, <scene name='pdbligand=8SN:(3~{S},7~{R},10~{R},11~{R},13~{S})-11-methyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic+acid'>8SN</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>

[[Category: ~~Roske, Y~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5nbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nbx OCA], [https://pdbe.org/5nbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nbx RCSB], [https://www.ebi.ac.uk/pdbsum/5nbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nbx ProSAT]</td></tr>

[[Category: Barone, M]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/ENAH_HUMAN ENAH_HUMAN] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).<ref>PMID:11696321</ref> <ref>PMID:18158903</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Barone M]]

[[Category: Roske Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5nbx is ON HOLD
+==ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-9]-OH==
+<StructureSection load='5nbx' size='340' side='right'caption='[[5nbx]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-Authors: Barone, M., Roske, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5nbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NBX FirstGlance]. <br>
-Description: ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-9]-OH
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2L5:2-CHLORO-L-PHENYLALANINE'>2L5</scene>, <scene name='pdbligand=8SN:(3~{S},7~{R},10~{R},11~{R},13~{S})-11-methyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic+acid'>8SN</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
-[[Category: Roske, Y]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nbx OCA], [https://pdbe.org/5nbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nbx RCSB], [https://www.ebi.ac.uk/pdbsum/5nbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nbx ProSAT]</span></td></tr>
-[[Category: Barone, M]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ENAH_HUMAN ENAH_HUMAN] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).<ref>PMID:11696321</ref> <ref>PMID:18158903</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Barone M]]
+[[Category: Roske Y]]