8b07: Difference between revisions
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==Crystal structure of monkeypox virus methyltransferase VP39 in complex with sinefungin== | |||
<StructureSection load='8b07' size='340' side='right'caption='[[8b07]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8b07]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Monkeypox_virus Monkeypox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B07 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b07 OCA], [https://pdbe.org/8b07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b07 RCSB], [https://www.ebi.ac.uk/pdbsum/8b07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b07 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A0F6N8X1_MONPV A0A0F6N8X1_MONPV] Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase VP55 that creates mRNA's poly(A) tail. In the presence of VP39, VP55 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.[ARBA:ARBA00003680][PIRNR:PIRNR003726] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Monkeypox virus]] | |||
[[Category: Boura E]] | |||
[[Category: Klima M]] | |||
[[Category: Silhan J]] | |||
Latest revision as of 08:15, 7 February 2024
Crystal structure of monkeypox virus methyltransferase VP39 in complex with sinefungin
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