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| [[Image:335d.gif|left|200px]]
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| {{Structure
| | ==THE CRYSTAL STRUCTURE OF THE DNA DECAMER D(GGCAATTGCG) CONTAINS BOTH MAJOR AND MINOR GROOVE BINDING G.(G.C) TRIPLETS== |
| |PDB= 335d |SIZE=350|CAPTION= <scene name='initialview01'>335d</scene>, resolution 2.400Å
| | <StructureSection load='335d' size='340' side='right'caption='[[335d]], [[Resolution|resolution]] 2.40Å' scene=''> |
| |SITE=
| | == Structural highlights == |
| |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
| | <table><tr><td colspan='2'>[[335d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=335D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=335D FirstGlance]. <br> |
| |ACTIVITY=
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| |GENE=
| | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| }}
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=335d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=335d OCA], [https://pdbe.org/335d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=335d RCSB], [https://www.ebi.ac.uk/pdbsum/335d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=335d ProSAT]</span></td></tr> |
| | | </table> |
| '''THE CRYSTAL STRUCTURE OF THE DNA DECAMER D(GGCAATTGCG) CONTAINS BOTH MAJOR AND MINOR GROOVE BINDING G.(G.C) TRIPLETS'''
| | __TOC__ |
| | | </StructureSection> |
| | | [[Category: Large Structures]] |
| ==Overview== | | [[Category: Neidle S]] |
| The crystal structure of the decamer d(GGCAATTGCG) has been determined at 2.4 A resolution. The central eight bases of each DNA single-strand base pair with a self-complementary strand to form an octamer B-DNA duplex. These duplexes lie end-to-end within the unit cell. The terminal 5'-G and G-3' bases of each decamer strand are unpaired, and interact with the neighbouring duplexes via interactions within both the major and minor groove. This results in base triplets of the type G-(G.C) and G*(G.C), with the third guanine base binding to a Watson-Crick G.C base pair from the major groove and the minor groove, respectively. The triplet interaction of the type G-(G.C) involves Hoogsteen hydrogen-bonding interactions between the two guanine bases. The minor- and major-groove base triplet interactions which exist within this structure act to stabilize the d(GCAATTGC)2 B-DNA octamer duplex.
| | [[Category: Nunn CM]] |
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| ==About this Structure== | |
| 335D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=335D OCA].
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| ==Reference== | |
| Structure of the DNA decamer d(GGCAATTGCG) contains both major- and minor-groove binding G.(G.C) base triplets., Nunn CM, Neidle S, Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):577-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9761852 9761852]
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| [[Category: Protein complex]] | |
| [[Category: Neidle, S.]]
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| [[Category: Nunn, C M.]]
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| [[Category: MG]] | |
| [[Category: a-dna]] | |
| [[Category: double helix]] | |
| [[Category: flipped-out base]] | |
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:54:44 2008''
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