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[[Image:348d.gif|left|200px]]


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==X-RAY CRYSTAL STRUCTURES OF THE DECAMER DGACCGCGGTC: LOW SALT CONCENTRATION==
The line below this paragraph, containing "STRUCTURE_348d", creates the "Structure Box" on the page.
<StructureSection load='348d' size='340' side='right'caption='[[348d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[348d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=348D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=348D FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=348d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=348d OCA], [https://pdbe.org/348d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=348d RCSB], [https://www.ebi.ac.uk/pdbsum/348d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=348d ProSAT]</span></td></tr>
{{STRUCTURE_348d|  PDB=348d  |  SCENE= }}
</table>
 
__TOC__
'''X-RAY CRYSTAL STRUCTURES OF THE DECAMER DGACCGCGGTC: LOW SALT CONCENTRATION'''
</StructureSection>
 
[[Category: Large Structures]]
 
[[Category: Finley JB]]
==Overview==
[[Category: Luo M]]
The X-ray crystal structure of the DNA decamer d(GACCGCGGTC), containing half the human papilloma virus E2 binding site, has been solved from two crystals grown at different ionic conditions (50 mM MgCl2and 50 mM spermine or 1.56 mM MgCl2and 1.56 mM spermine). Despite the variation in salt concentration, the two DNA structures are in a very similar, A-type DNA conformation, with helical axes curving towards the major groove. Although the salt concentrations do not effect the helical parameters or hydration to a large degree, there is a change in the overall helical curvature; 18 degrees and 31 degrees for the low and high salt structures, respectively. This curvature appears to be sequence specific and biologically relevant when compared with similar DNA structures, including the E2 binding site of a protein-DNA complex.
 
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=348D OCA].  
 
==Reference==
X-ray crystal structures of half the human papilloma virus E2 binding site: d(GACCGCGGTC)., Finley JB, Luo M, Nucleic Acids Res. 1998 Dec 15;26(24):5719-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9838004 9838004]
[[Category: Finley, J B.]]
[[Category: Luo, M.]]
[[Category: A-dna]]
[[Category: Double helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:16:41 2008''

Latest revision as of 08:39, 7 February 2024

X-RAY CRYSTAL STRUCTURES OF THE DECAMER DGACCGCGGTC: LOW SALT CONCENTRATION

348d, resolution 1.70Å

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