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==Crystal Structure of Fic domain containing AMPylator, VopS==
==Crystal Structure of Fic domain containing AMPylator, VopS==
<StructureSection load='3let' size='340' side='right' caption='[[3let]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3let' size='340' side='right'caption='[[3let]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3let]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_parahaemolyticus Vibrio parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LET FirstGlance]. <br>
<table><tr><td colspan='2'>[[3let]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus Vibrio parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LET FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vopS, VP 1686, VP1686 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=670 Vibrio parahaemolyticus])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.802&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide-nucleotide_adenylyltransferase Nicotinamide-nucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.1 2.7.7.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3let FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3let OCA], [https://pdbe.org/3let PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3let RCSB], [https://www.ebi.ac.uk/pdbsum/3let PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3let ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3let FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3let OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3let RCSB], [http://www.ebi.ac.uk/pdbsum/3let PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VOPS_VIBPA VOPS_VIBPA] Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific threonine residue of host Rho GTPases RhoA, Rac and Cdc42. The resulting AMPylation prevents the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in infected cells.<ref>PMID:19039103</ref> <ref>PMID:20410310</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Nicotinamide-nucleotide adenylyltransferase]]
[[Category: Large Structures]]
[[Category: Vibrio parahaemolyticus]]
[[Category: Vibrio parahaemolyticus]]
[[Category: Brautigam, C A]]
[[Category: Brautigam CA]]
[[Category: Grishin, N V]]
[[Category: Grishin NV]]
[[Category: Kinch, L N]]
[[Category: Kinch LN]]
[[Category: Luong, P H]]
[[Category: Luong PH]]
[[Category: Orth, K]]
[[Category: Orth K]]
[[Category: Tomchick, D R]]
[[Category: Tomchick DR]]
[[Category: Ampylation]]
[[Category: Effector]]
[[Category: Fic domain]]
[[Category: Nucleotidyltransferase]]
[[Category: T3ss]]
[[Category: Transferase]]
[[Category: Type iii]]
[[Category: Vibrio]]
[[Category: Virulence]]
Retrieved from "https://proteopedia.org/3let"