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==Dihydroorotase from Bacillus anthracis==
==Dihydroorotase from Bacillus anthracis==
<StructureSection load='3mpg' size='340' side='right' caption='[[3mpg]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3mpg' size='340' side='right'caption='[[3mpg]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3mpg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MPG FirstGlance]. <br>
<table><tr><td colspan='2'>[[3mpg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MPG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAS3739, BA_4027, GBAA_4027, pyrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mpg OCA], [https://pdbe.org/3mpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mpg RCSB], [https://www.ebi.ac.uk/pdbsum/3mpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mpg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mpg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mpg RCSB], [http://www.ebi.ac.uk/pdbsum/3mpg PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/PYRC_BACAN PYRC_BACAN]
Dihydroorotase (EC 3.5.2.3) catalyzes the reversible cyclization of N-carbamoyl-L-aspartate to L-dihydroorotate in the third step of the pyrimidine-biosynthesis pathway in Bacillus anthracis. A comparison is made between the structures of dihydroorotase from four different organisms, including B. anthracis dihydroorotase, and reveals substantial variations in the active site, dimer interface and overall tertiary structure. These differences demonstrate the utility of exploring multiple structures of a molecular target as expressed from different organisms and how these differences can be exploited for structure-based drug discovery.
 
Structure of dihydroorotase from Bacillus anthracis at 2.6 A resolution.,Mehboob S, Mulhearn DC, Truong K, Johnson ME, Santarsiero BD Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt, 11):1432-5. Epub 2010 Oct 27. PMID:21045288<ref>PMID:21045288</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==See Also==
</div>
*[[Dihydroorotase 3D structures|Dihydroorotase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
[[Category: Dihydroorotase]]
[[Category: Large Structures]]
[[Category: Johnson, M E]]
[[Category: Johnson ME]]
[[Category: Mehboob, S]]
[[Category: Mehboob S]]
[[Category: Santarsiero, B D]]
[[Category: Santarsiero BD]]
[[Category: Hydrolase]]
Retrieved from "https://proteopedia.org/3mpg"