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[[Image:1l2a.png|left|200px]]


{{STRUCTURE_1l2a|  PDB=1l2a  |  SCENE=  }}
==The Crystal Structure and Catalytic Mechanism of Cellobiohydrolase CelS, the Major Enzymatic Component of the Clostridium thermocellum cellulosome==
 
<StructureSection load='1l2a' size='340' side='right'caption='[[1l2a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===The Crystal Structure and Catalytic Mechanism of Cellobiohydrolase CelS, the Major Enzymatic Component of the Clostridium thermocellum cellulosome===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1l2a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetivibrio_thermocellus Acetivibrio thermocellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2A FirstGlance]. <br>
{{ABSTRACT_PUBMED_12096911}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PRD_900005:beta-cellobiose'>PRD_900005</scene>, <scene name='pdbligand=PRD_900020:beta-cellohexaose'>PRD_900020</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2a OCA], [https://pdbe.org/1l2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2a RCSB], [https://www.ebi.ac.uk/pdbsum/1l2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2a ProSAT]</span></td></tr>
[[1l2a]] is a 6 chain structure of [[Cellobiohydrolase]] and [[Glucanase]] with sequence from [http://en.wikipedia.org/wiki/Clostridium_thermocellum Clostridium thermocellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2A OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/GUNS_ACETH GUNS_ACETH] This enzyme catalyzes the exohydrolysis of 1,4-beta-glucosidic linkages in cellulose with a preference for amorphous or crystalline cellulose over carboxymethyl cellulose.<ref>PMID:20967294</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l2a ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cellobiohydrolase|Cellobiohydrolase]]
*[[Cellobiohydrolase 3D structures|Cellobiohydrolase 3D structures]]
*[[Glucanase|Glucanase]]
*[[Glucanase 3D structures|Glucanase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:012096911</ref><references group="xtra"/>
__TOC__
[[Category: Cellulase]]
</StructureSection>
[[Category: Clostridium thermocellum]]
[[Category: Acetivibrio thermocellus]]
[[Category: Alzari, P M.]]
[[Category: Large Structures]]
[[Category: Guimaraes, B G.]]
[[Category: Alzari PM]]
[[Category: Lytle, B L.]]
[[Category: Guimaraes BG]]
[[Category: Souchon, H.]]
[[Category: Lytle BL]]
[[Category: Wu, J H.D.]]
[[Category: Souchon H]]
[[Category: Alpha/alpha barrel]]
[[Category: Wu JHD]]
[[Category: Hydrolase]]
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