1l2a: Difference between revisions

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{{Seed}}
[[Image:1l2a.png|left|200px]]


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==The Crystal Structure and Catalytic Mechanism of Cellobiohydrolase CelS, the Major Enzymatic Component of the Clostridium thermocellum cellulosome==
The line below this paragraph, containing "STRUCTURE_1l2a", creates the "Structure Box" on the page.
<StructureSection load='1l2a' size='340' side='right'caption='[[1l2a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1l2a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetivibrio_thermocellus Acetivibrio thermocellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PRD_900005:beta-cellobiose'>PRD_900005</scene>, <scene name='pdbligand=PRD_900020:beta-cellohexaose'>PRD_900020</scene></td></tr>
{{STRUCTURE_1l2a| PDB=1l2a |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2a OCA], [https://pdbe.org/1l2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2a RCSB], [https://www.ebi.ac.uk/pdbsum/1l2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GUNS_ACETH GUNS_ACETH] This enzyme catalyzes the exohydrolysis of 1,4-beta-glucosidic linkages in cellulose with a preference for amorphous or crystalline cellulose over carboxymethyl cellulose.<ref>PMID:20967294</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l2a ConSurf].
<div style="clear:both"></div>


===The Crystal Structure and Catalytic Mechanism of Cellobiohydrolase CelS, the Major Enzymatic Component of the Clostridium thermocellum cellulosome===
==See Also==
 
*[[Cellobiohydrolase 3D structures|Cellobiohydrolase 3D structures]]
 
*[[Glucanase 3D structures|Glucanase 3D structures]]
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== References ==
The line below this paragraph, {{ABSTRACT_PUBMED_12096911}}, adds the Publication Abstract to the page
<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 12096911 is the PubMed ID number.
__TOC__
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</StructureSection>
{{ABSTRACT_PUBMED_12096911}}
[[Category: Acetivibrio thermocellus]]
 
[[Category: Large Structures]]
==About this Structure==
[[Category: Alzari PM]]
1L2A is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Clostridium_thermocellum Clostridium thermocellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2A OCA].
[[Category: Guimaraes BG]]
 
[[Category: Lytle BL]]
==Reference==
[[Category: Souchon H]]
<ref group="xtra">PMID:12096911</ref><references group="xtra"/>
[[Category: Wu JHD]]
[[Category: Cellulase]]
[[Category: Clostridium thermocellum]]
[[Category: Alzari, P M.]]
[[Category: Guimaraes, B G.]]
[[Category: Lytle, B L.]]
[[Category: Souchon, H.]]
[[Category: Wu, J H.D.]]
[[Category: Alpha/alpha barrel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:18:11 2009''
Retrieved from "https://proteopedia.org/1l2a"