1m99: Difference between revisions

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{{Seed}}
[[Image:1m99.png|left|200px]]


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==Crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum complexed with glutathione sulfonic acid==
The line below this paragraph, containing "STRUCTURE_1m99", creates the "Structure Box" on the page.
<StructureSection load='1m99' size='340' side='right'caption='[[1m99]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1m99]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M99 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTS:GLUTATHIONE+SULFONIC+ACID'>GTS</scene></td></tr>
{{STRUCTURE_1m99| PDB=1m99 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m99 OCA], [https://pdbe.org/1m99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m99 RCSB], [https://www.ebi.ac.uk/pdbsum/1m99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m99 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m9/1m99_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m99 ConSurf].
<div style="clear:both"></div>


===Crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum complexed with glutathione sulfonic acid===
==See Also==
 
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_12596270}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 12596270 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12596270}}
 
==About this Structure==
1M99 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M99 OCA].
 
==Reference==
Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum., Cardoso RM, Daniels DS, Bruns CM, Tainer JA, Proteins. 2003 Apr 1;51(1):137-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12596270 12596270]
[[Category: Glutathione transferase]]
[[Category: Schistosoma japonicum]]
[[Category: Schistosoma japonicum]]
[[Category: Single protein]]
[[Category: Bruns CM]]
[[Category: Bruns, C M.]]
[[Category: Cardoso RMF]]
[[Category: Cardoso, R M.F.]]
[[Category: Daniels DS]]
[[Category: Daniels, D S.]]
[[Category: Tainer JA]]
[[Category: Tainer, J A.]]
[[Category: Antigen]]
[[Category: Glutathione transferase]]
[[Category: Multigene family]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 23:28:39 2008''
Retrieved from "https://proteopedia.org/1m99"