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[[Image:1mxc.png|left|200px]]


{{STRUCTURE_1mxc|  PDB=1mxc  |  SCENE=  }}
==S-ADENOSYLMETHIONINE SYNTHETASE WITH 8-BR-ADP==
 
<StructureSection load='1mxc' size='340' side='right'caption='[[1mxc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
===S-ADENOSYLMETHIONINE SYNTHETASE WITH 8-BR-ADP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1mxc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MXC FirstGlance]. <br>
{{ABSTRACT_PUBMED_8611562}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABP:8-BROMOADENOSINE-5-DIPHOSPHATE'>ABP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mxc OCA], [https://pdbe.org/1mxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mxc RCSB], [https://www.ebi.ac.uk/pdbsum/1mxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mxc ProSAT]</span></td></tr>
[[1mxc]] is a 1 chain structure of [[S-adenosylmethionine synthetase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXC OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/METK_ECOLI METK_ECOLI] Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth.[HAMAP-Rule:MF_00086]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/1mxc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mxc ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[S-adenosylmethionine synthetase|S-adenosylmethionine synthetase]]
*[[S-adenosylmethionine synthetase 3D structures|S-adenosylmethionine synthetase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:008611562</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Methionine adenosyltransferase]]
[[Category: Large Structures]]
[[Category: Kamitori, S.]]
[[Category: Kamitori S]]
[[Category: Markham, G D.]]
[[Category: Markham GD]]
[[Category: Takusagawa, F.]]
[[Category: Takusagawa F]]
[[Category: Atp-binding]]
[[Category: One-carbon metabolism]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1mxc"