1pbk: Difference between revisions

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[[Image:1pbk.gif|left|200px]]


<!--
==HOMOLOGOUS DOMAIN OF HUMAN FKBP25==
The line below this paragraph, containing "STRUCTURE_1pbk", creates the "Structure Box" on the page.
<StructureSection load='1pbk' size='340' side='right'caption='[[1pbk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1pbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PBK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
{{STRUCTURE_1pbk| PDB=1pbk |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pbk OCA], [https://pdbe.org/1pbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pbk RCSB], [https://www.ebi.ac.uk/pdbsum/1pbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pbk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FKBP3_HUMAN FKBP3_HUMAN] FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pb/1pbk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pbk ConSurf].
<div style="clear:both"></div>


'''HOMOLOGOUS DOMAIN OF HUMAN FKBP25'''
==See Also==
 
*[[FKBP 3D structures|FKBP 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1PBK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBK OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Clardy, J.]]
[[Category: Clardy J]]
[[Category: Hung, D T.]]
[[Category: Hung DT]]
[[Category: Liang, J.]]
[[Category: Liang J]]
[[Category: Schreiber, S L.]]
[[Category: Schreiber SL]]
[[Category: Fkbp12 homologous domain of hfkbp25]]
[[Category: Isomerase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:54:35 2008''
Retrieved from "https://proteopedia.org/1pbk"