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[[Image:1pcl.gif|left|200px]]<br /><applet load="1pcl" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1pcl, resolution 2.2&Aring;" />
'''UNUSUAL STRUCTURAL FEATURES IN THE PARALLEL BETA-HELIX IN PECTATE LYASES'''<br />


==Overview==
==UNUSUAL STRUCTURAL FEATURES IN THE PARALLEL BETA-HELIX IN PECTATE LYASES==
BACKGROUND: A new type of domain structure, an all parallel beta class, has recently been observed in two pectate lyases, PelC and PelE. The atomic models have been analyzed to determine whether the new tertiary fold exhibits unusual structural features. RESULTS: The polypeptide backbone exhibits no new types of secondary structural elements. However, novel features occur in the amino acid side chain interactions. The side chain atoms form linear stacks that include asparagine ladders, serine stacks, aliphatic stacks, and ringed-residue stacks. A new type of beta-sandwich between parallel beta-sheets is observed with properties that are more characteristic of antiparallel beta-sheets. CONCLUSION: An analysis of the PelC and PelE structures, belonging to an all parallel beta structural class, reveals novel amino acid side chain interactions, a new type of beta-sandwich and an atypical amino acid composition of parallel beta-sheets. The findings are relevant to three-dimensional structural predictions.
<StructureSection load='1pcl' size='340' side='right'caption='[[1pcl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1pcl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_chrysanthemi Dickeya chrysanthemi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PCL FirstGlance]. <br>
1PCL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Erwinia_chrysanthemi Erwinia chrysanthemi]. Active as [http://en.wikipedia.org/wiki/Pectate_lyase Pectate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.2 4.2.2.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PCL OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pcl OCA], [https://pdbe.org/1pcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pcl RCSB], [https://www.ebi.ac.uk/pdbsum/1pcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pcl ProSAT]</span></td></tr>
==Reference==
</table>
Unusual structural features in the parallel beta-helix in pectate lyases., Yoder MD, Lietzke SE, Jurnak F, Structure. 1993 Dec 15;1(4):241-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8081738 8081738]
== Function ==
[[Category: Erwinia chrysanthemi]]
[https://www.uniprot.org/uniprot/PLYE1_DICCH PLYE1_DICCH] Involved in maceration and soft-rotting of plant tissue.
[[Category: Pectate lyase]]
== Evolutionary Conservation ==
[[Category: Single protein]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Jurnak, F.]]
Check<jmol>
[[Category: Keen, N T.]]
  <jmolCheckbox>
[[Category: Lietzke, S E.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/1pcl_consurf.spt"</scriptWhenChecked>
[[Category: lyase (acting on polysaccharides)]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:27:24 2008''
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pcl ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Dickeya chrysanthemi]]
[[Category: Large Structures]]
[[Category: Jurnak F]]
[[Category: Keen NT]]
[[Category: Lietzke SE]]
Retrieved from "https://proteopedia.org/1pcl"