1rh2: Difference between revisions

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{{Seed}}
[[Image:1rh2.png|left|200px]]


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==RECOMBINANT HUMAN INTERFERON-ALPHA 2B==
The line below this paragraph, containing "STRUCTURE_1rh2", creates the "Structure Box" on the page.
<StructureSection load='1rh2' size='340' side='right'caption='[[1rh2]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1rh2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RH2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1rh2| PDB=1rh2 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rh2 OCA], [https://pdbe.org/1rh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rh2 RCSB], [https://www.ebi.ac.uk/pdbsum/1rh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rh2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IFNA2_HUMAN IFNA2_HUMAN] Produced by macrophages, IFN-alpha have antiviral activities.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/1rh2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rh2 ConSurf].
<div style="clear:both"></div>


===RECOMBINANT HUMAN INTERFERON-ALPHA 2B===
==See Also==
 
*[[Interferon 3D structures|Interferon 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_8994971}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8994971 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_8994971}}
 
==About this Structure==
1RH2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RH2 OCA].
 
==Reference==
Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography., Radhakrishnan R, Walter LJ, Hruza A, Reichert P, Trotta PP, Nagabhushan TL, Walter MR, Structure. 1996 Dec 15;4(12):1453-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8994971 8994971]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Walter, M R.]]
[[Category: Walter MR]]
[[Category: 4 helix bundle]]
[[Category: Anti-viral]]
[[Category: Cytokine]]
[[Category: Immunomodulator]]
[[Category: Interferon]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:33:04 2008''

Latest revision as of 08:23, 14 February 2024

RECOMBINANT HUMAN INTERFERON-ALPHA 2B

1rh2, resolution 2.90Å

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