1rxt: Difference between revisions

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New page: left|200px<br /> <applet load="1rxt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rxt, resolution 3.0Å" /> '''Crystal structure of...
 
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[[Image:1rxt.gif|left|200px]]<br />
<applet load="1rxt" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1rxt, resolution 3.0&Aring;" />
'''Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.'''<br />


==Disease==
==Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.==
Known disease associated with this structure: Thyroid carcinoma, nonmedullary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606240 606240]]
<StructureSection load='1rxt' size='340' side='right'caption='[[1rxt]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1rxt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXT FirstGlance]. <br>
1RXT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CO and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RXT OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxt OCA], [https://pdbe.org/1rxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxt RCSB], [https://www.ebi.ac.uk/pdbsum/1rxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rx/1rxt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rxt ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Abeles, R.H.]]
[[Category: Abeles RH]]
[[Category: Frey, G.]]
[[Category: Frey G]]
[[Category: Petsko, G.A.]]
[[Category: Petsko GA]]
[[Category: Ringe, D.]]
[[Category: Ringe D]]
[[Category: Wang, Y.]]
[[Category: Wang Y]]
[[Category: Yang, J.]]
[[Category: Yang J]]
[[Category: CO]]
[[Category: SO4]]
[[Category: alpha-beta structure; unique n-myristoyltransferase fold]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:08:10 2007''

Latest revision as of 08:26, 14 February 2024

Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.

1rxt, resolution 3.00Å

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