1x9e: Difference between revisions

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[[Image:1x9e.png|left|200px]]


{{STRUCTURE_1x9e|  PDB=1x9e  |  SCENE=  }}
==Crystal structure of HMG-CoA synthase from Enterococcus faecalis==
 
<StructureSection load='1x9e' size='340' side='right'caption='[[1x9e]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
===Crystal structure of HMG-CoA synthase from Enterococcus faecalis===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1x9e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X9E FirstGlance]. <br>
{{ABSTRACT_PUBMED_16245942}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x9e OCA], [https://pdbe.org/1x9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x9e RCSB], [https://www.ebi.ac.uk/pdbsum/1x9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x9e ProSAT]</span></td></tr>
[[1x9e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X9E OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/HMGCS_ENTFL HMGCS_ENTFL] Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds.<ref>PMID:12107122</ref> <ref>PMID:23794621</ref>
<ref group="xtra">PMID:016245942</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/1x9e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x9e ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
[[Category: Hydroxymethylglutaryl-CoA synthase]]
[[Category: Large Structures]]
[[Category: II, J W.Burgner.]]
[[Category: Burgner II JW]]
[[Category: Rodwell, V W.]]
[[Category: Rodwell VW]]
[[Category: Stauffacher, C V.]]
[[Category: Stauffacher CV]]
[[Category: Steussy, C N.]]
[[Category: Steussy CN]]
[[Category: Sutherlin, A.]]
[[Category: Sutherlin A]]
[[Category: Vartia, A A.]]
[[Category: Vartia AA]]
[[Category: Lyase]]
[[Category: Thiolase family]]
Retrieved from "https://proteopedia.org/1x9e"