|
|
| (11 intermediate revisions by the same user not shown) |
| Line 1: |
Line 1: |
| [[Image:243d.gif|left|200px]]
| |
|
| |
|
| {{Structure
| | ==STRUCTURE OF THE DNA OCTANUCLEOTIDE D(ACGTACGT)2== |
| |PDB= 243d |SIZE=350|CAPTION= <scene name='initialview01'>243d</scene>, resolution 1.900Å
| | <StructureSection load='243d' size='340' side='right'caption='[[243d]], [[Resolution|resolution]] 1.90Å' scene=''> |
| |SITE=
| | == Structural highlights == |
| |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>
| | <table><tr><td colspan='2'>[[243d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=243D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=243D FirstGlance]. <br> |
| |ACTIVITY=
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| |GENE=
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=243d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=243d OCA], [https://pdbe.org/243d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=243d RCSB], [https://www.ebi.ac.uk/pdbsum/243d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=243d ProSAT]</span></td></tr> |
| |DOMAIN=
| | </table> |
| |RELATEDENTRY=
| | __TOC__ |
| |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=243d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=243d OCA], [http://www.ebi.ac.uk/pdbsum/243d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=243d RCSB]</span>
| | </StructureSection> |
| }}
| | [[Category: Large Structures]] |
| | | [[Category: Adams A]] |
| '''STRUCTURE OF THE DNA OCTANUCLEOTIDE D(ACGTACGT)2'''
| | [[Category: Cardin CJ]] |
| | | [[Category: Wakelin LPG]] |
| | | [[Category: Wilcock DJ]] |
| ==Overview==
| |
| d(ACGTACGT), C(78)H(84)N(30)O(32)P(7).20H(2)O, M(r) (DNA) = 2170, tetragonal, P4(3)2(1)2 (No 96), a = 42.845 (1), b = 42.845(1), c = 24.804 (1) A, V = 45532.5 (2) A(3), z = 8,lambda(MoKalpha) = 0.71069 A, micro (MoKalpha) = 0.10 mm(-1), T = 295 K, R = 0.18 for 1994 unique reflections between 5.0 and 1.9 A resolution. The self-complementary octanucleotide d(ACGTACGT)(2) has been crystallized and its structure determined to a resolution of 1.9 A. The asymmetric unit consists of a single strand of octamer with 20 water molecules. It is only the second example of an octanucleotide having terminal A.T base pairs whose structure has been determined by X-ray crystallography. The sequence adopts the modified A-type conformation found for all octanucleotide duplexes studied to date with the helix bent by approximately 15 degrees and an average tilt angle of 0 degrees. Unusually the data collection was carried out using a 3 kW molybdenum sealed-tube source. The conformational details are discussed in comparison with other closely related sequences.
| |
| | |
| ==About this Structure==
| |
| 243D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=243D OCA].
| |
| | |
| ==Reference==
| |
| Structure of the DNA octanucleotide d(ACGTACGT)2., Wilcock DJ, Adams A, Cardin CJ, Wakelin LP, Acta Crystallogr D Biol Crystallogr. 1996 May 1;52(Pt 3):481-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299669 15299669]
| |
| [[Category: Protein complex]] | |
| [[Category: Adams, A.]] | |
| [[Category: Cardin, C J.]] | |
| [[Category: Wakelin, L P.G.]] | |
| [[Category: Wilcock, D J.]] | |
| [[Category: a-dna]]
| |
| [[Category: double helix]]
| |
| | |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:45:04 2008''
| |
