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[[Image:244d.jpg|left|200px]]


{{Structure
==THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX==
|PDB= 244d |SIZE=350|CAPTION= <scene name='initialview01'>244d</scene>, resolution 1.200&Aring;
<StructureSection load='244d' size='340' side='right'caption='[[244d]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
<table><tr><td colspan='2'>[[244d]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=244D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=244D FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=244d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=244d OCA], [https://pdbe.org/244d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=244d RCSB], [https://www.ebi.ac.uk/pdbsum/244d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=244d ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=244d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=244d OCA], [http://www.ebi.ac.uk/pdbsum/244d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=244d RCSB]</span>
__TOC__
}}
</StructureSection>
 
[[Category: Large Structures]]
'''THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX'''
[[Category: Laughlan G]]
 
[[Category: Lilley DMJ]]
 
[[Category: Luisi B]]
==Overview==
[[Category: Moody PCE]]
Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.
[[Category: Moore MH]]
 
[[Category: Murchie AIH]]
==About this Structure==
[[Category: Norman DG]]
244D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=244D OCA].
 
==Reference==
The high-resolution crystal structure of a parallel-stranded guanine tetraplex., Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B, Science. 1994 Jul 22;265(5171):520-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8036494 8036494]
[[Category: Protein complex]]
[[Category: Laughlan, G.]]
[[Category: Lilley, D M.J.]]
[[Category: Luisi, B.]]
[[Category: Moody, P C.E.]]
[[Category: Moore, M H.]]
[[Category: Murchie, A I.H.]]
[[Category: Norman, D G.]]
[[Category: parallel-stranded tetraplex]]
[[Category: quadruple helix]]
[[Category: unusual dna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:45:06 2008''
Retrieved from "https://proteopedia.org/244d"