2b0l: Difference between revisions

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{{Seed}}
[[Image:2b0l.png|left|200px]]


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==C-terminal DNA binding domain of transcriptional pleiotropic repressor CodY.==
The line below this paragraph, containing "STRUCTURE_2b0l", creates the "Structure Box" on the page.
<StructureSection load='2b0l' size='340' side='right'caption='[[2b0l]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2b0l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B0L FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0l OCA], [https://pdbe.org/2b0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b0l RCSB], [https://www.ebi.ac.uk/pdbsum/2b0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b0l ProSAT]</span></td></tr>
{{STRUCTURE_2b0l|  PDB=2b0l  |  SCENE=  }}
</table>
 
== Function ==
===C-terminal DNA binding domain of transcriptional pleiotropic repressor CodY.===
[https://www.uniprot.org/uniprot/CODY_BACSU CODY_BACSU] DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.<ref>PMID:8830686</ref> <ref>PMID:11331605</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_16488888}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 16488888 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/2b0l_consurf.spt"</scriptWhenChecked>
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    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_16488888}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b0l ConSurf].
2B0L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0L OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
The structure of CodY, a GTP- and isoleucine-responsive regulator of stationary phase and virulence in gram-positive bacteria., Levdikov VM, Blagova E, Joseph P, Sonenshein AL, Wilkinson AJ, J Biol Chem. 2006 Apr 21;281(16):11366-73. Epub 2006 Feb 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16488888 16488888]
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Blagova, E.]]
[[Category: Blagova E]]
[[Category: Joseph, P.]]
[[Category: Joseph P]]
[[Category: Levdikov, V M.]]
[[Category: Levdikov VM]]
[[Category: Sonenshein, A L.]]
[[Category: Sonenshein AL]]
[[Category: Wilkinson, A J.]]
[[Category: Wilkinson AJ]]
[[Category: Cody]]
[[Category: Dna-binding]]
[[Category: Nucleotide-binding]]
[[Category: Repressor]]
[[Category: Transcription regulation]]
[[Category: Winged hth motif.]]
 
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Retrieved from "https://proteopedia.org/2b0l"