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[[Image:2be1.png|left|200px]]


{{STRUCTURE_2be1| PDB=2be1 | SCENE= }}
==Structure of the compact lumenal domain of yeast Ire1==
<StructureSection load='2be1' size='340' side='right'caption='[[2be1]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2be1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BE1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.983&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2be1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2be1 OCA], [https://pdbe.org/2be1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2be1 RCSB], [https://www.ebi.ac.uk/pdbsum/2be1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2be1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRE1_YEAST IRE1_YEAST] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.<ref>PMID:8663458</ref> <ref>PMID:8670804</ref> <ref>PMID:9323131</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2be1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2be1 ConSurf].
<div style="clear:both"></div>


===Structure of the compact lumenal domain of yeast Ire1===
==See Also==
 
*[[Ire1|Ire1]]
{{ABSTRACT_PUBMED_16365312}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2be1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BE1 OCA].
</StructureSection>
 
[[Category: Large Structures]]
==Reference==
<ref group="xtra">PMID:016365312</ref><references group="xtra"/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Credle, J J.]]
[[Category: Credle JJ]]
[[Category: Finer-Moore, J S.]]
[[Category: Finer-Moore JS]]
[[Category: Papa, F R.]]
[[Category: Papa FR]]
[[Category: Stroud, R M.]]
[[Category: Stroud RM]]
[[Category: Walter, P.]]
[[Category: Walter P]]
[[Category: Peptide-binding groove peptide-mediated oligomerization beta-propeller]]
[[Category: Transcription]]
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