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{{STRUCTURE_2fl8|  PDB=2fl8  |  SCENE=  }}
===Fitting of the gp10 trimer structure into the cryoEM map of the bacteriophage T4 baseplate in the hexagonal conformation.===
{{ABSTRACT_PUBMED_16554069}}


==About this Structure==
==Fitting of the gp10 trimer structure into the cryoEM map of the bacteriophage T4 baseplate in the hexagonal conformation.==
[[2fl8]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FL8 OCA].  
<SX load='2fl8' size='340' side='right' viewer='molstar' caption='[[2fl8]], [[Resolution|resolution]] 12.00&Aring;' scene=''>
 
== Structural highlights ==
==Reference==
<table><tr><td colspan='2'>[[2fl8]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FL8 FirstGlance]. <br>
<ref group="xtra">PMID:016554069</ref><references group="xtra"/>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 12&#8491;</td></tr>
[[Category: Enterobacteria phage t4]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fl8 OCA], [https://pdbe.org/2fl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fl8 RCSB], [https://www.ebi.ac.uk/pdbsum/2fl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fl8 ProSAT]</span></td></tr>
[[Category: Leiman, P G.]]
</table>
[[Category: Mesyanzhinov, V V.]]
== Function ==
[[Category: Rossmann, M G.]]
[https://www.uniprot.org/uniprot/BP10_BPT4 BP10_BPT4] Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate (PubMed:16554069). During infection, the baseplate undergoes a conformational change from a dome-shaped to a star-shaped structure. At this point, gp10 rotates and acts as a lever that unfolds the short tail fibers, which then interact with host cell surface receptors. Involved in the tail assembly.<ref>PMID:16554069</ref> <ref>PMID:21129200</ref>
[[Category: Shneider, M M.]]
== Evolutionary Conservation ==
[[Category: Bacteriophage t4]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Baseplate]]
Check<jmol>
[[Category: Evolution]]
  <jmolCheckbox>
[[Category: Gp10]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/2fl8_consurf.spt"</scriptWhenChecked>
[[Category: Structural comparison]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Tail]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Virus-viral protein complex]]
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fl8 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</SX>
[[Category: Escherichia virus T4]]
[[Category: Large Structures]]
[[Category: Leiman PG]]
[[Category: Mesyanzhinov VV]]
[[Category: Rossmann MG]]
[[Category: Shneider MM]]
Retrieved from "https://proteopedia.org/2fl8"