2fm5: Difference between revisions

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[[Image:2fm5.png|left|200px]]


{{STRUCTURE_2fm5|  PDB=2fm5  |  SCENE=  }}
==Crystal structure of PDE4D2 in complex with inhibitor L-869299==
 
<StructureSection load='2fm5' size='340' side='right'caption='[[2fm5]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
===Crystal structure of PDE4D2 in complex with inhibitor L-869299===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2fm5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FM5 FirstGlance]. <br>
{{ABSTRACT_PUBMED_16539372}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M99:(R)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHYL)PYRIDINE+1-OXIDE'>M99</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fm5 OCA], [https://pdbe.org/2fm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fm5 RCSB], [https://www.ebi.ac.uk/pdbsum/2fm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fm5 ProSAT]</span></td></tr>
[[2fm5]] is a 4 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM5 OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.  Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[https://omim.org/entry/614613 614613]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
== Function ==
[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/2fm5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fm5 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:016539372</ref><references group="xtra"/>
__TOC__
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aspiotis, R.]]
[[Category: Large Structures]]
[[Category: Huai, Q.]]
[[Category: Aspiotis R]]
[[Category: Huang, Z.]]
[[Category: Huai Q]]
[[Category: Ke, H.]]
[[Category: Huang Z]]
[[Category: Macdonald, D.]]
[[Category: Ke H]]
[[Category: Robinson, H.]]
[[Category: Macdonald D]]
[[Category: Sun, Y.]]
[[Category: Robinson H]]
[[Category: Wang, H.]]
[[Category: Sun Y]]
[[Category: Camp signal]]
[[Category: Wang H]]
[[Category: Enantiomer binding]]
[[Category: Hydrolase]]
[[Category: Inhibitor selectivity]]
[[Category: L-869299]]
[[Category: Pde4]]
Retrieved from "https://proteopedia.org/2fm5"