2g37: Difference between revisions

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{{Seed}}
[[Image:2g37.png|left|200px]]


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==Structure of Thermus thermophilus L-proline dehydrogenase==
The line below this paragraph, containing "STRUCTURE_2g37", creates the "Structure Box" on the page.
<StructureSection load='2g37' size='340' side='right'caption='[[2g37]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2g37]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G37 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
{{STRUCTURE_2g37|  PDB=2g37  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g37 OCA], [https://pdbe.org/2g37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g37 RCSB], [https://www.ebi.ac.uk/pdbsum/2g37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g37 ProSAT]</span></td></tr>
 
</table>
===Structure of Thermus thermophilus L-proline dehydrogenase===
== Function ==
 
[https://www.uniprot.org/uniprot/PRODH_THET2 PRODH_THET2] Converts proline to delta-1-pyrroline-5-carboxylate (PubMed:17344208, PubMed:18426222). Has significant activity against O(2) producing superoxide during proline oxidation catalytic cycle (PubMed:17344208).<ref>PMID:17344208</ref> <ref>PMID:18426222</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/2g37_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_17344208}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2G37 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G37 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g37 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus., White TA, Krishnan N, Becker DF, Tanner JJ, J Biol Chem. 2007 May 11;282(19):14316-27. Epub 2007 Mar 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17344208 17344208]
<references/>
[[Category: Proline dehydrogenase]]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Thermus thermophilus]]
[[Category: Large Structures]]
[[Category: Tanner, J J.]]
[[Category: Thermus thermophilus HB27]]
[[Category: White, T A.]]
[[Category: Tanner JJ]]
[[Category: Beta8-alpha8-barrel]]
[[Category: White TA]]
[[Category: Flavoenzyme]]
 
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