2g8a: Difference between revisions

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[[Image:2g8a.gif|left|200px]]


{{Structure
==Lactobacillus casei Y261M in complex with substrate, dUMP==
|PDB= 2g8a |SIZE=350|CAPTION= <scene name='initialview01'>2g8a</scene>, resolution 2.40&Aring;
<StructureSection load='2g8a' size='340' side='right'caption='[[2g8a]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE 5'-MONOPHOSPHATE'>UMP</scene>
<table><tr><td colspan='2'>[[2g8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G8A FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE= thya ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1582 Lactobacillus casei])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8a OCA], [https://pdbe.org/2g8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g8a RCSB], [https://www.ebi.ac.uk/pdbsum/2g8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g8a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g8a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g8a ConSurf].
<div style="clear:both"></div>


'''Lactobacillus casei Y261M in complex with substrate, dUMP'''
==See Also==
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2G8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8A OCA].
[[Category: Lacticaseibacillus casei]]
[[Category: Lactobacillus casei]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Finer-Moore JS]]
[[Category: Thymidylate synthase]]
[[Category: Stroud RM]]
[[Category: Finer-Moore, J S.]]
[[Category: Stroud, R M.]]
[[Category: UMP]]
[[Category: active site mutation]]
[[Category: alpha-beta protein]]
[[Category: beta sheet]]
[[Category: dump complex]]
[[Category: methyltransferase]]
 
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Retrieved from "https://proteopedia.org/2g8a"