2h0q: Difference between revisions

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{{Seed}}
[[Image:2h0q.png|left|200px]]


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==Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)==
The line below this paragraph, containing "STRUCTURE_2h0q", creates the "Structure Box" on the page.
<StructureSection load='2h0q' size='340' side='right'caption='[[2h0q]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2h0q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H0Q FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h0q OCA], [https://pdbe.org/2h0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h0q RCSB], [https://www.ebi.ac.uk/pdbsum/2h0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h0q ProSAT]</span></td></tr>
{{STRUCTURE_2h0q|  PDB=2h0q  |  SCENE=  }}
</table>
 
== Function ==
===Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)===
[https://www.uniprot.org/uniprot/UBS3B_MOUSE UBS3B_MOUSE] Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.<ref>PMID:14738763</ref> <ref>PMID:19733910</ref> <ref>PMID:20585042</ref> <ref>PMID:17679096</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/2h0q_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17679096}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h0q ConSurf].
2H0Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0Q OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling., Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N, Mol Cell. 2007 Aug 3;27(3):486-97. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17679096 17679096]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Carpino N]]
[[Category: Carpino, N.]]
[[Category: Ford B]]
[[Category: Ford, B.]]
[[Category: Nassar N]]
[[Category: Nassar, N.]]
[[Category: Pgm]]
[[Category: Signaling protein]]
[[Category: Sts-1]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:42:21 2008''
Retrieved from "https://proteopedia.org/2h0q"