2hf0: Difference between revisions

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{{Seed}}
[[Image:2hf0.png|left|200px]]


<!--
==Bifidobacterium longum bile salt hydrolase==
The line below this paragraph, containing "STRUCTURE_2hf0", creates the "Structure Box" on the page.
<StructureSection load='2hf0' size='340' side='right'caption='[[2hf0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2hf0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HF0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hf0 OCA], [https://pdbe.org/2hf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2hf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hf0 ProSAT]</span></td></tr>
{{STRUCTURE_2hf0|  PDB=2hf0  |  SCENE=  }}
</table>
 
== Function ==
===Bifidobacterium longum bile salt hydrolase===
[https://www.uniprot.org/uniprot/CBH_BIFLN CBH_BIFLN] Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in all six major human bile salts, namely glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a slight preference for glycine-conjugated bile acids as substrates (PubMed:10831430, PubMed:16905539). Is totally inactive toward penicillin V (PubMed:16905539).<ref>PMID:10831430</ref> <ref>PMID:16905539</ref>  
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
<!--
Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_16905539}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 16905539 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/2hf0_consurf.spt"</scriptWhenChecked>
-->
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_16905539}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hf0 ConSurf].
2HF0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HF0 OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:16905539</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Bifidobacterium longum]]
[[Category: Bifidobacterium longum]]
[[Category: Choloylglycine hydrolase]]
[[Category: Large Structures]]
[[Category: Brannigan, J A.]]
[[Category: Brannigan JA]]
[[Category: Kumar, R S.]]
[[Category: Kumar RS]]
[[Category: Suresh, C G.]]
[[Category: Suresh CG]]
[[Category: Alpha]]
[[Category: Beta]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:48:32 2009''

Latest revision as of 09:32, 14 February 2024

Bifidobacterium longum bile salt hydrolase

2hf0, resolution 2.30Å

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