2hqc: Difference between revisions

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{{Seed}}
[[Image:2hqc.png|left|200px]]


<!--
==Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway==
The line below this paragraph, containing "STRUCTURE_2hqc", creates the "Structure Box" on the page.
<StructureSection load='2hqc' size='340' side='right'caption='[[2hqc]], [[Resolution|resolution]] 3.56&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2hqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HQC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.56&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hqc OCA], [https://pdbe.org/2hqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hqc RCSB], [https://www.ebi.ac.uk/pdbsum/2hqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hqc ProSAT]</span></td></tr>
{{STRUCTURE_2hqc|  PDB=2hqc  |  SCENE=  }}
</table>
 
== Function ==
===Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway===
[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
<!--
Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_17015668}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 17015668 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/2hqc_consurf.spt"</scriptWhenChecked>
-->
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_17015668}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hqc ConSurf].
2HQC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQC OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway., Su CC, Li M, Gu R, Takatsuka Y, McDermott G, Nikaido H, Yu EW, J Bacteriol. 2006 Oct;188(20):7290-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17015668 17015668]
__TOC__
[[Category: Escherichia coli]]
</StructureSection>
[[Category: Single protein]]
[[Category: Escherichia coli K-12]]
[[Category: Gu, R.]]
[[Category: Large Structures]]
[[Category: Li, M.]]
[[Category: Gu R]]
[[Category: McDermott, G.]]
[[Category: Li M]]
[[Category: Nikaido, H.]]
[[Category: McDermott G]]
[[Category: Su, C C.]]
[[Category: Nikaido H]]
[[Category: Takatsuka, Y.]]
[[Category: Su C-C]]
[[Category: Yu, E W.]]
[[Category: Takatsuka Y]]
[[Category: Membrane protein]]
[[Category: Yu EW]]
[[Category: Multidrug efflux pump]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:03:19 2008''
Retrieved from "https://proteopedia.org/2hqc"