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[[Image:2hvl.jpg|left|200px]]


{{Structure
==Crystal structure of the HePTP catalytic domain C270S mutant==
|PDB= 2hvl |SIZE=350|CAPTION= <scene name='initialview01'>2hvl</scene>, resolution 2.40&Aring;
<StructureSection load='2hvl' size='340' side='right'caption='[[2hvl]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
<table><tr><td colspan='2'>[[2hvl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HVL FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE= PTPN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hvl OCA], [https://pdbe.org/2hvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hvl RCSB], [https://www.ebi.ac.uk/pdbsum/2hvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hvl ProSAT]</span></td></tr>
|RELATEDENTRY=[[1zc0|1ZC0]], [[2gpo|2GPO]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hvl OCA], [http://www.ebi.ac.uk/pdbsum/2hvl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hvl RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/PTN7_HUMAN PTN7_HUMAN] Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.<ref>PMID:1510684</ref> <ref>PMID:1530918</ref> <ref>PMID:9624114</ref> <ref>PMID:10206983</ref> <ref>PMID:10559944</ref> <ref>PMID:10702794</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/2hvl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hvl ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the HePTP catalytic domain C270S mutant'''
==See Also==
 
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2HVL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVL OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Critton D]]
[[Category: Critton, D.]]
[[Category: Page R]]
[[Category: Page, R.]]
[[Category: Ragusa M]]
[[Category: Ragusa, M.]]
[[Category: heptp]]
[[Category: human tyrosine phosphatase catalytic domain]]
[[Category: hydrolase]]
[[Category: lc-ptp]]
[[Category: ptpn7]]
[[Category: substrate-trapping mutant]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:36:02 2008''

Latest revision as of 09:34, 14 February 2024

Crystal structure of the HePTP catalytic domain C270S mutant

2hvl, resolution 2.40Å

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