2i7n: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2i7n.png|left|200px]]


<!--
==Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA==
The line below this paragraph, containing "STRUCTURE_2i7n", creates the "Structure Box" on the page.
<StructureSection load='2i7n' size='340' side='right'caption='[[2i7n]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7N FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
{{STRUCTURE_2i7n| PDB=2i7n |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [https://pdbe.org/2i7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [https://www.ebi.ac.uk/pdbsum/2i7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PANK1_HUMAN PANK1_HUMAN] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7n_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7n ConSurf].
<div style="clear:both"></div>


===Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA===
==See Also==
 
*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_17631502}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17631502 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17631502}}
 
==About this Structure==
2I7N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA].
 
==Reference==
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder., Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW, J Biol Chem. 2007 Sep 21;282(38):27984-93. Epub 2007 Jul 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17631502 17631502]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Pantothenate kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Allali-Hassani A]]
[[Category: Allali-Hassani, A.]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Hong BS]]
[[Category: Hong, B S.]]
[[Category: Loppnau P]]
[[Category: Loppnau, P.]]
[[Category: Park HW]]
[[Category: Park, H W.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Tempel W]]
[[Category: Tempel, W.]]
[[Category: Wang L]]
[[Category: Wang, L.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Pank]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  5 10:38:51 2008''
Retrieved from "https://proteopedia.org/2i7n"