2p54: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(11 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2p54.png|left|200px]]


<!--
==a crystal structure of PPAR alpha bound with SRC1 peptide and GW735==
The line below this paragraph, containing "STRUCTURE_2p54", creates the "Structure Box" on the page.
<StructureSection load='2p54' size='340' side='right'caption='[[2p54]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2p54]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P54 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=735:2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC+ACID'>735</scene></td></tr>
{{STRUCTURE_2p54| PDB=2p54 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p54 OCA], [https://pdbe.org/2p54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p54 RCSB], [https://www.ebi.ac.uk/pdbsum/2p54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p54 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/2p54_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p54 ConSurf].
<div style="clear:both"></div>


===a crystal structure of PPAR alpha bound with SRC1 peptide and GW735===
==See Also==
 
*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
 
== References ==
<!--  
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_17243659}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 17243659 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_17243659}}
 
==About this Structure==
2P54 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P54 OCA].
 
==Reference==
<ref group="xtra">PMID:17243659</ref><references group="xtra"/>
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Lambert, M H.]]
[[Category: Large Structures]]
[[Category: Montana, V G.]]
[[Category: Lambert MH]]
[[Category: Pianetti, P M.]]
[[Category: Montana VG]]
[[Category: Sierra, M L.]]
[[Category: Pianetti PM]]
[[Category: Xu, H E.]]
[[Category: Sierra ML]]
[[Category: Xu, R X.]]
[[Category: Xu HE]]
[[Category: Ppar alpha gw735 src1 agonist hdlc]]
[[Category: Xu RX]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:21:24 2009''

Latest revision as of 09:08, 21 February 2024

a crystal structure of PPAR alpha bound with SRC1 peptide and GW735

2p54, resolution 1.79Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2p54&oldid=4062297"