2qlp: Difference between revisions

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{{Seed}}
[[Image:2qlp.png|left|200px]]


<!--
==Bifunctional dCTP deaminase:dUTPase from Mycobacterium tuberculosis, apo form==
The line below this paragraph, containing "STRUCTURE_2qlp", creates the "Structure Box" on the page.
<StructureSection load='2qlp' size='340' side='right'caption='[[2qlp]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2qlp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QLP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
{{STRUCTURE_2qlp| PDB=2qlp |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qlp OCA], [https://pdbe.org/2qlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qlp RCSB], [https://www.ebi.ac.uk/pdbsum/2qlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qlp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCDB_MYCTU DCDB_MYCTU] Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase. Affinity for dCTP and dUTP are very similar.<ref>PMID:18164314</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ql/2qlp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qlp ConSurf].
<div style="clear:both"></div>


===Bifunctional dCTP deaminase:dUTPase from Mycobacterium tuberculosis, apo form===
==See Also==
 
*[[Deaminase 3D structures|Deaminase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_18164314}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 18164314 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_18164314}}
[[Category: Mycobacterium tuberculosis H37Rv]]
 
[[Category: Christophersen S]]
==About this Structure==
[[Category: Harris P]]
2QLP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QLP OCA].
[[Category: Willemoes M]]
 
==Reference==
Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis., Helt SS, Thymark M, Harris P, Aagaard C, Dietrich J, Larsen S, Willemoes M, J Mol Biol. 2008 Feb 15;376(2):554-69. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18164314 18164314]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: DCTP deaminase]]
[[Category: Christophersen, S.]]
[[Category: Harris, P.]]
[[Category: Willemoes, M.]]
[[Category: Distorted beta barrel]]
[[Category: Hydrolase]]
[[Category: Nucleotide metabolism]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:55:27 2008''
Retrieved from "https://proteopedia.org/2qlp"