2qv6: Difference between revisions

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{{Seed}}
[[Image:2qv6.png|left|200px]]


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==GTP cyclohydrolase III from M. jannaschii (MJ0145) complexed with GTP and metal ions==
The line below this paragraph, containing "STRUCTURE_2qv6", creates the "Structure Box" on the page.
<StructureSection load='2qv6' size='340' side='right'caption='[[2qv6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2qv6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QV6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
{{STRUCTURE_2qv6| PDB=2qv6 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qv6 OCA], [https://pdbe.org/2qv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qv6 RCSB], [https://www.ebi.ac.uk/pdbsum/2qv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qv6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GCH3_METJA GCH3_METJA] Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.[HAMAP-Rule:MF_00608]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qv/2qv6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qv6 ConSurf].
<div style="clear:both"></div>


===GTP cyclohydrolase III from M. jannaschii (MJ0145) complexed with GTP and metal ions===
==See Also==
 
*[[Cyclohydrolase 3D structures|Cyclohydrolase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_18052207}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 18052207 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_18052207}}
 
==About this Structure==
2QV6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QV6 OCA].
 
==Reference==
A new use for a familiar fold: the X-ray crystal structure of GTP-bound GTP cyclohydrolase III from Methanocaldococcus jannaschii reveals a two metal ion catalytic mechanism., Morrison SD, Roberts SA, Zegeer AM, Montfort WR, Bandarian V, Biochemistry. 2008 Jan 8;47(1):230-42. Epub 2007 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18052207 18052207]
[[Category: GTP cyclohydrolase IIa]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Single protein]]
[[Category: Bandarian V]]
[[Category: Bandarian, V.]]
[[Category: Roberts SA]]
[[Category: Roberts, S A.]]
[[Category: Enzyme]]
[[Category: Fapy]]
[[Category: Gtp]]
[[Category: Hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:04:28 2008''

Latest revision as of 09:18, 21 February 2024

GTP cyclohydrolase III from M. jannaschii (MJ0145) complexed with GTP and metal ions

2qv6, resolution 2.00Å

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