2rcz: Difference between revisions

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{{Seed}}
[[Image:2rcz.png|left|200px]]


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==Structure of the second PDZ domain of ZO-1==
The line below this paragraph, containing "STRUCTURE_2rcz", creates the "Structure Box" on the page.
<StructureSection load='2rcz' size='340' side='right'caption='[[2rcz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2rcz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCZ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcz OCA], [https://pdbe.org/2rcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rcz RCSB], [https://www.ebi.ac.uk/pdbsum/2rcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rcz ProSAT]</span></td></tr>
{{STRUCTURE_2rcz|  PDB=2rcz  |  SCENE=  }}
</table>
 
== Function ==
===Structure of the second PDZ domain of ZO-1===
[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_17928286}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17928286 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rcz_consurf.spt"</scriptWhenChecked>
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    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_17928286}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rcz ConSurf].
2RCZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCZ OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
Domain swapping within PDZ2 is responsible for dimerization of ZO proteins., Fanning AS, Lye MF, Anderson JM, Lavie A, J Biol Chem. 2007 Dec 28;282(52):37710-6. Epub 2007 Oct 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17928286 17928286]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Lavie, A.]]
[[Category: Lavie A]]
[[Category: Lye, M F.]]
[[Category: Lye MF]]
[[Category: Cell junction]]
[[Category: Domain-swapping]]
[[Category: Membrane]]
[[Category: Pdz]]
[[Category: Phosphorylation]]
[[Category: Protein binding]]
[[Category: Sh3 domain]]
[[Category: Tight junction]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:24:23 2008''
Retrieved from "https://proteopedia.org/2rcz"