3bch: Difference between revisions

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[[Image:3bch.jpg|left|200px]]


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==Crystal Structure of the Human Laminin Receptor Precursor==
The line below this paragraph, containing "STRUCTURE_3bch", creates the "Structure Box" on the page.
<StructureSection load='3bch' size='340' side='right'caption='[[3bch]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bch]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BCH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bch OCA], [https://pdbe.org/3bch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bch RCSB], [https://www.ebi.ac.uk/pdbsum/3bch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bch ProSAT]</span></td></tr>
{{STRUCTURE_3bch|  PDB=3bch  |  SCENE= }}
</table>
 
== Function ==
'''Crystal Structure of the Human Laminin Receptor Precursor'''
[https://www.uniprot.org/uniprot/RSSA_HUMAN RSSA_HUMAN] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.<ref>PMID:6300843</ref> <ref>PMID:16263087</ref> <ref>PMID:15516338</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
The human laminin receptor (LamR) interacts with many ligands, including laminin, prions, Sindbis virus, and the polyphenol (-)-epigallocatechin-3-gallate (EGCG), and has been implicated in a number of diseases. LamR is overexpressed on tumor cells, and targeting LamR elicits anti-cancer effects. Here, we report the crystal structure of human LamR, which provides insights into its function and should facilitate the design of novel therapeutics targeting LamR.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/3bch_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
3BCH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCH OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bch ConSurf].
Crystal structure of the human laminin receptor precursor., Jamieson KV, Wu J, Hubbard SR, Meruelo D, J Biol Chem. 2008 Feb 8;283(6):3002-5. Epub 2007 Dec 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18063583 18063583]
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hubbard, S R.]]
[[Category: Hubbard SR]]
[[Category: Jamieson, K V.]]
[[Category: Jamieson KV]]
[[Category: Meruelo, D.]]
[[Category: Meruelo D]]
[[Category: Wu, J.]]
[[Category: Wu J]]
[[Category: Acetylation]]
[[Category: Cell adhesion]]
[[Category: Cytoplasm]]
[[Category: Laminin receptor]]
[[Category: P40 ribosomal protein]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Ribonucleoprotein]]
[[Category: Ribosomal protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:38:10 2008''
Retrieved from "https://proteopedia.org/3bch"